When a doctor says the word "cancer," fear takes over. But what if the test that triggered that fear was fundamentally flawed? The CA125 blood test, routinely used to screen women for ovarian cancer, may be leading thousands into unnecessary surgeries, chemotherapy, and lifelong trauma—all based on misleading results.

How the CA125 Test Works (And Why It Fails)

The test measures levels of CA125 protein in the blood, with a arbitrary cutoff:

• <35 U/mL = "Normal"
• >35 U/mL = "Possible Cancer"

The shocking truth? This protein naturally fluctuates due to:
✔ Menstrual cycles
✔ Fibroids/cysts (common in women over 40)
✔ Infections (even a cold can spike levels)
✔ Common medications (birth control, painkillers)

"Declaring cancer risk based on CA125 alone is like predicting rain because you saw a cloud." — Dr. Biswaroop Roy Chowdhury

The Domino Effect of a False Positive

Unnecessary Biopsies – Invasive procedures with risks of infection/complications

PET Scans – Radiation exposure equivalent to 800 chest X-rays

Chemo/Radiation – Immune system destruction for a "cancer" that may not exist

Psychological Trauma – Anxiety/depression from false diagnoses

Who’s Most Vulnerable?

• Women over 40 (natural cysts common)
• Those on birth control or NSAIDs (artificially elevates CA125)
• Anyone with IBS or chronic inflammation

Safer Alternatives for Early Detection

Instead of relying solely on CA125:
🔍 Symptom Tracking – Bloating, pelvic pain, appetite changes
🔍 Ultrasound First – Less invasive imaging before blood tests
🔍 HE4 Protein Test – More specific biomarker (when combined with CA125)

What to Do If Your Doctor Orders a CA125

Ask: "Could my result be high for non-cancer reasons?"

Request repeat testing (levels vary daily)

Insist on ultrasound confirmation before biopsies

Final Thought: "A test should reduce uncertainty—not create it. True prevention starts with understanding the limits of screening."